Afriendofminewasfondofdrawinghorse.Hedrewthehorsesverywell,buthealwaysbeganthetail.NowitistheWesternruletobeginattheheadofthehorse,thatiswhyIwassurprised.Itstruckmethatitcouldnotreallymakeanydifferencewhethertheartistbeginsattheheadorthetailorthebelly(肚子)orthefootofthehorse,ifhereallyknowshisbusiness.Andmostgreatartistswhoreallyknowtheirbusinessdonotfollowotherpeople’srule.Theymaketheirownrules.Everyoneofthemdoeshisworkinawaypeculiar(奇特的)tohimself;andthepeculiaritymeansonlythathefindsitmoreeasytoworkinthatway.
Nowtheverysamethingistruetoliterature(文学).Andthequestion,"HowshallIbegin?"onlymeansthatyouwanttobeginattheheadinsteadofbeginningatthetailorsomewhereelse.Thatis,youarenotyetexperienced(有经验的)enoughtotrusttoyourownpowers.Whenyoubecomemoreexperiencedyouwill
neveraskthequestion,andIthinkthatyouwilloftenbeginatthetail--thatistosay,youwillwritetheendofthestorybeforeyouhaveeventhoughtofthebeginning.
1.Afriendofthewriter’sdrewthehorses____.
A.verywell
B.inthewayofwesternrule
C.inthewayofhisownrule
D.alloftheabove
2.Thewriterwassurprisedbecause____.
A.theartistbegantodrawattheheadofthehorse
B.theartistbegantodrawatthetailofthehorse
C.theartistmadehisownrule
D.theartistdidnotfollowotherpeople’srule
3.Youarenotyetexperiencedbecause____.
A.youdon’tknowwheretobegin
B.youwanttobeginattheheadinsteadofbeginningatthetail
C.youalwaysaskedquestion
D.youdonottrusttoyourownpowers
4.Whenyoubecomemoreexperiencedyouwill____.
A.neveraskquestion
B.oftenbeginatthetail
C.shouldwritetheendofthestory
D.shouldthinkofthebeginning
5.Thetopicofthepassageis______.
A.Howtodrawahorse
B.Howtowriteastory
C.Howtomakeyourownrules
D.Trusttoyourownpowers
Everyyear,about10millionofthe150millionworkersintheEuropeanCommunityareaffectedbyincidents,”accidents”ordiseasesatwork.
1.Thefailureofahigh-profilecholesteroldrughasthrownaspotlightonthecomplicatedmachinerythatregulatescholesterollevels.Butmanyresearchersremainconfidentthatdrugstoboostlevelsof'good'cholesterolarestilloneofthemostpromisingmeanstocombatspirallingheartdisease.
2.DrugcompanyPfizerannouncedon2Decemberthatitwascancellingallclinicaltrialsoftorcetrapib，adrugdesignedtoraiseheart-protectivehigh-densitylipoproteins(HDLs).Inatrialof15000patients，asafetyboardfoundthatmorepeoplediedorsufferedcardiovascularproblemsaftertakingthedrugplusacholesterol-loweringstatinthanthoseinacontrolgroupwhotookthestatinalone.
3.Thenewscameasakickintheteethtomanycardiologistsbecauseearliertestsinanimalsandpeoplesuggesteditwouldlowerratesofcardiovasculardisease."Therehavebeennoredflagstomyknowledge,"saysJohnChapman，aspecialistinlipoproteinsandatherosclerosisattheNationalInstituteforHealthandMedicalResearch(INSERM)inPariswhohasalsostudiedtorcetrapib."Thiscancellationcameasacompleteshock."
4.TorcetrapibisoneofthemostadvancedofanewbreedofdrugsdesignedtoraiselevelsofHDLs，whichferrycholesteroloutofartery-cloggingplaquestotheliverforremovalfromthebody.Specifically，torcetrapibblocksaproteincalledcholesterolestertransferprotein(CETP)，whichnormallytransfersthecholesterolfromhigh-densitylipoproteinstolowdensity，plaque-promotingones.Statins，incontrast，mainlyworkbyloweringthe'bad'low-densitylipoproteins.
Underpressure
5.Researchersarenowtryingtoworkoutwhyandhowthedrugbackfired，somethingthatwillnotbecomeclearuntiltheclinicaldetailsarereleasedbyPfizer.Onehintliesinevidencefromearliertrialsthatitslightlyraisesbloodpressureinsomepatients.Itwasthoughtthatthismildproblemwouldbeoffsetbytheheartbenefitsofthedrug.Butitispossiblethatitactuallyprovedfatalinsomepatientswhoalreadysufferedhighbloodpressure.Ifbloodpressureistheexplanation，itwouldactuallybegoodnewsfordrugdevelopersbecauseitsuggeststhattheproblemsarespecifictothiscompound.OtherprototypedrugsthatarebeingdevelopedtoblockCETPworkinaslightlydifferentwayandmightnotsufferthesamedownfall.
6.ButitisalsopossiblethatthewholeideaofblockingCETPisflawed，saysMotiKashyap，whodirectsatherosclerosisresearchattheVAMedicalCenterinLongBeach，California.WhenHDLsexcretecholesterolintheliver，theyactuallyrelyonLDLsforpartofthisprocess.SoinhibitingCETP，whichpreventsthetransferofcholesterolfromHDLtoLDL，mightactuallycauseanabnormalandirreversibleaccumulationofcholesterolinthebody."You'reblockingaphysiologicmechanismtoeliminatecholesterolandeffectivelyconstipatingthepathway,"saysKashyap.Goingup
7.Mostresearchersremainconfidentthatelevatinghighdensitylipoproteinslevelsbyonemeansoranotherisoneofthebestroutesforhelpingheartdiseasepatients.ButHDLsarecomplexandnotentirelyunderstood.Oneapproveddrug，calledniacin，isknowntobothraiseHDLandreducecardiovascularriskbutalsocausesanunpleasantsensationofheatandtingling.Researchersareexploringwhethertheycanbypassthissideeffectandwhetherniacincanlowerdiseaseriskmorethanstatinsalone.Scientistsarealsoworkingonseveralothermeanstobumpuphigh-densitylipoproteinsby，forexample，introducingsyntheticHDLs."Theonlythingweknowisdeadinthewateristorcetrapib，notthewholeideaofraisingHDL,"saysMichaelMiller，directorofpreventivecardiologyattheUniversityofMarylandMedicalCenter，Baltimore.
Questions7-13
Matchtorcetrapib，HDLs，statinandCETPwiththeirfunctions(Questions8-13)..WritethecorrectletterA，B，CorDinboxes8-13onyouranswersheet.NBYoumayuseanylettermorethanonce.
7.Ithasbeenadministeredtoover10,000subjectsinaclinicaltrial.
8.Itcouldhelpridhumanbodyofcholesterol.
9.Researchersareyettofindmoreaboutit.
10.Itwasusedtoreducethelevelofcholesterol.
11.AccordingtoKashyap，itmightleadtounwantedresultifit'sblocked.
12.Itproducedcontradictoryresultsindifferenttrials.
13.ItcouldinhibitLDLs.Listofchoices
A.TorcetrapicB.HDLSC.StatinD.CETP