I hoped we can do business together and looking forward to hearing from you soon.

4.Torcetrapib is one of the most advanced of a new breed of drugs designed to raise levels of HDLs，which ferry cholesterol out of artery-clogging plaques to the liver for removal from the body.Specifically，torcetrapib blocks a protein called cholesterol ester transfer protein (CETP)，which normally transfers the cholesterol from high-density lipoproteins to low density，plaque-promoting ones.Statins，in contrast，mainly work by lowering the 'bad' low-density lipoproteins.

Under pressure

5.Researchers are now trying to work out why and how the drug backfired，something that will not become clear until the clinical details are released by Pfizer.One hint lies in evidence from earlier trials that it slightly raises blood pressure in some patients.It was thought that this mild problem would be offset by the heart benefits of the drug.But it is possible that it actually proved fatal in some patients who already suffered high blood pressure.If blood pressure is the explanation，it would actually be good news for drug developers because it suggests that the problems are specific to this compound.Other prototype drugs that are being developed to block CETP work in a slightly different way and might not suffer the same downfall.

6.But it is also possible that the whole idea of blocking CETP is flawed，says Moti Kashyap，who directs atherosclerosis research at the VA Medical Center in Long Beach，California.When HDLs excrete cholesterol in the liver，they actually rely on LDLs for part of this process.So inhibiting CETP，which prevents the transfer of cholesterol from HDL to LDL，might actually cause an abnormal and irreversible accumulation of cholesterol in the body."You're blocking a physiologic mechanism to eliminate cholesterol and effectively constipating the pathway," says Kashyap.Going up

7.Most researchers remain confident that elevating high density lipoproteins levels by one means or another is one of the best routes for helping heart disease patients.But HDLs are complex and not entirely understood.One approved drug，called niacin，is known to both raise HDL and reduce cardiovascular risk but also causes an unpleasant sensation of heat and tingling.Researchers are exploring whether they can bypass this side effect and whether niacin can lower disease risk more than statins alone.Scientists are also working on several other means to bump up high-density lipoproteins by，for example，introducing synthetic HDLs."The only thing we know is dead in the water is torcetrapib，not the whole idea of raising HDL," says Michael Miller，director of preventive cardiology at the University of Maryland Medical Center，Baltimore.

Questions 7-13

Match torcetrapib，HDLs，statin and CETP with their functions (Questions 8-13)..Write the correct letter A，B，C or D in boxes 8-13 on your answer sheet.NB You may use any letter more than once.

7.It has been administered to over 10,000 subjects in a clinical trial.

8.It could help rid human body of cholesterol.

9.Researchers are yet to find more about it.

10.It was used to reduce the level of cholesterol.

11.According to Kashyap，it might lead to unwanted result if it's blocked.

12.It produced contradictory results in different trials.

13.It could inhibit LDLs.List of choices

A.TorcetrapicB.HDLSC.StatinD.CETP

1.The failure of a high-profile cholesterol drug has thrown a spotlight on the complicated machinery that regulates cholesterol levels.But many researchers remain confident that drugs to boost levels of 'good' cholesterol are still one of the most promising means to combat spiralling heart disease.

2.Drug company Pfizer announced on 2 December that it was cancelling all clinical trials of torcetrapib，a drug designed to raise heart-protective high-density lipoproteins (HDLs).In a trial of 15000 patients，a safety board found that more people died or suffered cardiovascular problems after taking the drug plus a cholesterol-lowering statin than those in a control group who took the statin alone.

3.The news came as a kick in the teeth to many cardiologists because earlier tests in animals and people suggested it would lower rates of cardiovascular disease."There have been no red flags to my knowledge," says John Chapman，a specialist in lipoproteins and atherosclerosis at the National Institute for Health and Medical Research (INSERM) in Paris who has also studied torcetrapib."This cancellation came as a complete shock."

4.Torcetrapib is one of the most advanced of a new breed of drugs designed to raise levels of HDLs，which ferry cholesterol out of artery-clogging plaques to the liver for removal from the body.Specifically，torcetrapib blocks a protein called cholesterol ester transfer protein (CETP)，which normally transfers the cholesterol from high-density lipoproteins to low density，plaque-promoting ones.Statins，in contrast，mainly work by lowering the 'bad' low-density lipoproteins.

Under pressure

5.Researchers are now trying to work out why and how the drug backfired，something that will not become clear until the clinical details are released by Pfizer.One hint lies in evidence from earlier trials that it slightly raises blood pressure in some patients.It was thought that this mild problem would be offset by the heart benefits of the drug.But it is possible that it actually proved fatal in some patients who already suffered high blood pressure.If blood pressure is the explanation，it would actually be good news for drug developers because it suggests that the problems are specific to this compound.Other prototype drugs that are being developed to block CETP work in a slightly different way and might not suffer the same downfall.

6.But it is also possible that the whole idea of blocking CETP is flawed，says Moti Kashyap，who directs atherosclerosis research at the VA Medical Center in Long Beach，California.When HDLs excrete cholesterol in the liver，they actually rely on LDLs for part of this process.So inhibiting CETP，which prevents the transfer of cholesterol from HDL to LDL，might actually cause an abnormal and irreversible accumulation of cholesterol in the body."You're blocking a physiologic mechanism to eliminate cholesterol and effectively constipating the pathway," says Kashyap.Going up

7.Most researchers remain confident that elevating high density lipoproteins levels by one means or another is one of the best routes for helping heart disease patients.But HDLs are complex and not entirely understood.One approved drug，called niacin，is known to both raise HDL and reduce cardiovascular risk but also causes an unpleasant sensation of heat and tingling.Researchers are exploring whether they can bypass this side effect and whether niacin can lower disease risk more than statins alone.Scientists are also working on several other means to bump up high-density lipoproteins by，for example，introducing synthetic HDLs."The only thing we know is dead in the water is torcetrapib，not the whole idea of raising HDL," says Michael Miller，director of preventive cardiology at the University of Maryland Medical Center，Baltimore.

Questions 7-13

Match torcetrapib，HDLs，statin and CETP with their functions (Questions 8-13)..Write the correct letter A，B，C or D in boxes 8-13 on your answer sheet.NB You may use any letter more than once.

7.It has been administered to over 10,000 subjects in a clinical trial.

8.It could help rid human body of cholesterol.

9.Researchers are yet to find more about it.

10.It was used to reduce the level of cholesterol.

11.According to Kashyap，it might lead to unwanted result if it's blocked.

12.It produced contradictory results in different trials.

13.It could inhibit LDLs.List of choices

A.TorcetrapicB.HDLSC.StatinD.CETP

.For the sake of our long-term friendship ,we are going to accept the price reduction on the radios. How about 6% off?

Asian economies will continue to expand rapidly in the next two years on the back of foreign investments, exports and domestic demand, but will not be free of worries, according to a recent securities company economic report. Massive infrastructure spending, the benefits of past investments and deregulation and growing regional trade will push along regional growth.

The report tipped China’s gross domestic product to grow by 9.5 per cent in 1996 and 10.5 per cent in 1997, and Hong Kong’s to grow by 4.3 and 5.0 per cent. Singapore’s real GDP was forecast to grow by 7.6 and 7.4 per cent, Malaysia’s by 8.6 and 8.1 per cent, Thailand’s by 8.8 and 8.4 per cent, Indonesia’s by 7.3 and 7.1 per cent and Philippines’ by 5.6 and 5.8 per cent.

“However, all is not rosy,” cautioned the report, which listed overheating as the region’s biggest challenge in the short term and skilled-labor shortages in the long run.

It cited strains from rapid growth that had begun to stretch current account deficits and spur inflation in some regional economies, which could prevent their central banks from lowering interest rates.

“This implies that economic vulnerability to unexpected shocks will remain high,” the report said, forecasting a further tightening of monetary policy in countries such as the Philippines and Malaysia, and no significant easing in Thailand, Indonesia and China.

Crosby Securities also cited massive new investment programs generated by demands on infrastructure such as power, telecommunications and transport which had fuelled over-heating.

It said Asia would also face a bigger challenge from newly deregulating economies in Eastern Europe which offered lower costs and better-educated workers to foreign investors.

Asia’s main foreign investors should, however, continue to expand their presence in the region, the securities house said, noting new trends of intra-Asian investment.

Singapore is shifting its lower value-added disc drive and electronics industry to Malaysia, which in turn is moving some of its garment-making and consumer electronics manufacturing to Indonesia and Thailand. Thailand, Malaysia and Singapore are increasingly investing in Viet Nam, Myanmar and Laos.

“Asia will benefit from this trend in several ways,” the report said.

( )1Asia economy will continue to grow because of _____________.

A. foreign investment B. demands in Asian countries.

C. export D. all of the above

( )2 In the next 2 years, the highest economic growth will appear in ____________.

A. Singapore B. Thailand

C. Hong Kong D. China

( )3 Years later, the problem in Asian economy may be _________________.

A. too little investment B. too much investment

C. not enough qualified labors D. monetary instability

( )4 According to this report, economic changes in East Europe are ___________.

A. harmful B. challenging

C. helpful D. useless

( )5 The report is about the prospect of Asian economy.

A. optimistic B. pessimistic

C. more optimistic than pessimistic D. more pessimistic than optimistic

题目：通过自荐信建立商务关系。

What problems do staff usually have when they are under the burden of a heavy workload?

Read the text about career-planning services.

Choose the best sentence from the opposite page to fill each of the gaps .

For each gap 9– 14, mark one letter (A-H) on your Answer Sheet .

Do not use any letter more than once .

There is an example at the beginning .(0)

Your Career Path Can Lead You Anywhere

We used to be advised to plan our careers. We were told to make a plan during the later stages of our education and continue with it through our working lives.(0)_____ some people still see careers in this way. However, to pursue a single option for life has always been unrealistic.

Planning for a single career assumes that we set out with a full understanding of our likes and dislikes and the employment opportunities open to us. (9)____ For most people this degree of certainty about the future does not exist.

Our initial choice of career path and employer is often based on inadequate knowledge and false perceptions. But with age and experience, we develop new interests and aptitudes and our priorities alter. The structure of the employment market and, indeed of employment itself, is subject to change as both new technologies and new work systems are introduced (10) _____ We must face the uncertainties of a portfolio career.

It is clear from the recent past that we cannot foresee the changes which will affect our working lives. The pace of change is accelerating , as a result of which traditional career plans will be of very limited use. (11)_____ They will need updating to reflect changes in our own interests as well as in the external work environment. Flexible workers already account for about half the workforce. (12)______ We are likely to face periods as contract workers, self-employed freelances, consultants, temps or part-timers.

Many employers encourage staff to write a personal development development (PDP) (13)_____ Although some people use it only to review the skills needed for their job, a PDP could be the nucleus of wider career plan –setting out alternative long-term learning needs and a plan of self-development.

A report issued by the Institute of Employment Studies advises people to enhance their employability by moving from traditional technical skills towards the attainment of a range of transferable skills. (14)_____ Instead, special schemes should be established to encourage people to examine their effectiveness and to consider a wider range of needs.

0 A B C D E F G H

A This dual effect means that the relationship between employers and workers has evolved to such and extent that we can no longer expect a long-term relationship with one employer.

B. It carries an implicit assumption that we ourselves, and the jobs we enter, will change little during our working lives.

C. This growth suggests that a career plan should not be expressed only in terms of full-time employment but should make provision for the possibility of becoming one of the.

D this is a summary of one’s personal learning needs and an action plan to meet them.

E Consequently, they must now accommodate a number of objectives and enable us to prepare for each on a contingency basis.

F However, it warns that employers often identify training needs through formal appraisals, which take too narrow a view of development.

G . Such a freelance of consultant would be constantly in demand.

H We were expected to work towards that one clear goal and to consider a career change as a bad thing.

Annual leave

never ask the question, and I think that you will often begin at the tail --that is to say, you will write the end of the story before you have even thought of the beginning.

1. A friend of the writer’s drew the horses ____.

A. very well

B. in the way of western rule

C. in the way of his own rule

D. all of the above

2. The writer was surprised because ____.

A. the artist began to draw at the head of the horse

B. the artist began to draw at the tail of the horse

C. the artist made his own rule

D. the artist did not follow other people’s rule

3. You are not yet experienced because ____.

A. you don’t know where to begin

B. you want to begin at the head instead of beginning at the tail

C. you always asked question

D. you do not trust to your own powers

4. When you become more experienced you will ____.

A. never ask question

B. often begin at the tail

C. should write the end of the story

D. should think of the beginning

5. The topic of the passage is ______.

A. How to draw a horse

B. How to write a story

C. How to make your own rules

D. Trust to your own powers

A friend of mine was fond of drawing horse. He drew the horses very well,but he always began the tail. Now it is the Western rule to begin at the head of the horse, that is why I was surprised. It struck me that it could not really make any difference whether the artist begins at the head or the tail or the belly(肚子) or the foot of the horse, if he really knows his business. And most great artists who really know their business do not follow other people’s rule.They make their own rules. Every one of them does his work in a way peculiar(奇特的) to himself; and the peculiarity means only that he finds it more easy to work in that way.

Now the very same thing is true to literature(文学). And the question, "How shall I begin?" only means that you want to begin at the head instead of beginning at the tail or somewhere else. That is, you are not yet experienced(有经验的) enough to trust to your own powers. When you become more experienced you will

never ask the question, and I think that you will often begin at the tail --that is to say, you will write the end of the story before you have even thought of the beginning.

1. A friend of the writer’s drew the horses ____.

A. very well

B. in the way of western rule

C. in the way of his own rule

D. all of the above

2. The writer was surprised because ____.

A. the artist began to draw at the head of the horse

B. the artist began to draw at the tail of the horse

C. the artist made his own rule

D. the artist did not follow other people’s rule

3. You are not yet experienced because ____.

A. you don’t know where to begin

B. you want to begin at the head instead of beginning at the tail

C. you always asked question

D. you do not trust to your own powers

4. When you become more experienced you will ____.

A. never ask question

B. often begin at the tail

C. should write the end of the story

D. should think of the beginning

5. The topic of the passage is ______.

A. How to draw a horse

B. How to write a story

C. How to make your own rules

D. Trust to your own powers

Some visitors are interested in other countries' cultures and traditions. How they learn other cultures and traditions? Why this is interesting to some visitors but not to others?