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new weapon to fight cancer
1. British scientists are preparing to launch trials of a radical new way to
fight cancer, which kills tumours by infecting them with viruses like the common
cold.
2. If successful, virus therapy could eventually form a third pillar
alongside radiotherapy and chemotherapy in the standard arsenal against cancer,
while avoiding some of the debilitating side-effects.
3. Leonard Seymour, a professor of gene therapy at Oxford University, who has
been working on the virus therapy with colleagues in London and the US, will
lead the trials later this year. Cancer Research UK said yesterday that it was
excited by the potential of Prof Seymour’s pioneering techniques.
4. One of the country’s leading geneticists, Prof Seymour has been working
with viruses that kill cancer cells directly, while avoiding harm to healthy
tissue. "In principle, you’ve got something which could be many times more
effective than regular chemotherapy," he said.
5. Cancer-killing viruses exploit the fact that cancer cells suppress the
body’s local immune system. "If a cancer doesn’t do that, the immune system
wipes it out. If you can get a virus into a tumour, viruses find them a very
good place to be because there’s no immune system to stop them replicating. You
can regard it as the cancer’s Achilles’ heel."
6. Only a small amount of the virus needs to get to the cancer. "They
replicate, you get a million copies in each cell and the cell bursts and they
infect the tumour cells adjacent and repeat the process," said Prof Seymour.
7. Preliminary research on mice shows that the viruses work well on tumours
resistant to standard cancer drugs. "It’s an interesting possibility that they
may have an advantage in killing drug-resistant tumours, which could be quite
different to anything we’ve had before."
8. Researchers have known for some time that viruses can kill tumour cells
and some aspects of the work have already been published in scientific journals.
American scientists have previously injected viruses directly into tumours but
this technique will not work if the cancer is inaccessible or has spread
throughout the body.
9. Prof Seymour’s innovative solution is to mask the virus from the body’s
immune system, effectively allowing the viruses to do what chemotherapy drugs do
- spread through the blood and reach tumours wherever they are. The big hurdle
has always been to find a way to deliver viruses to tumours via the bloodstream
without the body’s immune system destroying them on the way.
10. "What we’ve done is make chemical modifications to the virus to put a
polymer coat around it - it’s a stealth virus when you inject it," he said.
11. After the stealth virus infects the tumour, it replicates, but the copies
do not have the chemical modifications. If they escape from the tumour, the
copies will be quickly recognised and mopped up by the body’s immune system.
12. The therapy would be especially useful for secondary cancers, called
metastases, which sometimes spread around the body after the first tumour
appears. "There’s an awful statistic of patients in the west ... with malignant
cancers; 75% of them go on to die from metastases," said Prof Seymour.
13. Two viruses are likely to be examined in the first clinical trials:
adenovirus, which normally causes a cold-like illness, and vaccinia, which
causes cowpox and is also used in the vaccine against smallpox. For safety
reasons, both will be disabled to make them less pathogenic in the trial, but
Prof Seymour said he eventually hopes to use natural viruses.
14. The first trials will use uncoated adenovirus and vaccinia and will be
delivered locally to liver tumours, in order to establish whether the treatment
is safe in humans and what dose of virus will be needed. Several more years of
trials will be needed, eventually also on the polymer-coated viruses, before the
therapy can be considered for use in the NHS. Though the approach will be
examined at first for cancers that do not respond to conventional treatments,
Prof Seymour hopes that one day it might be applied to all cancers.
Questions 1-6
Do the following statements agree with the information given in the reading
passage? For questions 1-6 write
TRUE if the statement agrees with the information
FALSE if the statement contradicts the information
NOT GIVEN if there is no information on this in the passage
1.Virus therapy, if successful, has an advantage in eliminating
side-effects.
2.Cancer Research UK is quite hopeful about Professor Seymour’s work on the
virus therapy.
3.Virus can kill cancer cells and stop them from growing again.
4.Cancer’s Achilles’ heel refers to the fact that virus may stay safely in a
tumor and replicate.
5.To infect the cancer cells, a good deal of viruses should be injected into
the tumor.
6.Researches on animals indicate that virus could be used as a new way to
treat drug-resistant tumors.
Question 7-9
Based on the reading passage, choose the appropriate letter from A-D for each
answer.
7.Information about researches on viruses killing tumor cells can be
found
(A) on TV
(B) in magazines
(C) on internet
(D) in newspapers
8.To treat tumors spreading out in body, researchers try to
(A) change the body’ immune system
(B) inject chemotherapy drugs into bloodstream.
(C) increase the amount of injection
(D) disguise the viruses on the way to tumors.
9.When the chemical modified virus in tumor replicates, the copies
(A) will soon escape from the tumor and spread out.
(B) will be wiped out by the body’s immune system.
(C) will be immediately recognized by the researchers.
(D) will eventually stop the tumor from spreading out.
Questions 10-13
Complete the sentences below. Choose your answers from the list of words. You
can only use each word once.
NB There are more words in the list than spaces so you will not use them
all.
In the first clinical trials, scientists will try to ……10…… adenovirus and
vaccinia, so both the viruses will be less pathogenic than the ……11…….These
uncoated viruses will be applied directly to certain areas to confirm safety on
human beings and the right ……12…… needed. The experiments will firstly be
……13……to the treatment of certain cancers
Felicity Lawrence
Thursday December 28, 2006
The Guardian
1. Consumers are to be presented with two rival new year advertising
campaigns as the Food Standards Agency goes public in its battle with the
industry over the labelling of unhealthy foods.
2. The Guardian has learned that the FSA will launch a series of 10-second
television adverts in January telling shoppers how to follow a red, amber and
green traffic light labelling system on the front of food packs, which is
designed to tackle Britain’s obesity epidemic.
3. The campaign is a direct response to a concerted attempt by leading food
manufacturers and retailers, including Kellogg’s and Tesco, to derail the
system. The industry fears that traffic lights would demonise entire categories
of foods and could seriously damage the market for those that are fatty, salty
or high in sugar.
4. The UK market for breakfast cereals is worth ￡1.27bn a year and the
manufacturers fear it will be severely dented if red light labels are put on
packaging drawing attention to the fact that the majority are high in salt
and/or sugar.
5. The industry is planning a major marketing campaign for a competing
labelling system which avoids colour-coding in favour of information about the
percentage of "guideline daily amounts" (GDAs) of fat, salt and sugar contained
in their products.
6. The battle for the nation’s diet comes as new rules on television
advertising come into force in January which will bar adverts for unhealthy
foods from commercial breaks during programmes aimed at children. Sources at the
TV regulators are braced for a legal challenge from the industry and have
described the lobbying efforts to block any new ad ban or colour-coded labelling
as "the most ferocious we’ve ever experienced".
7. Ofcom’s chief executive, Ed Richards, said: "We are prepared to face up to
any legal action from the industry, but we very much hope it will not be
necessary." The FSA said it was expecting an onslaught from the industry in
January. Senior FSA officials said the manufacturers’ efforts to undermine its
proposals on labelling could threaten the agency’s credibility.
8. Terrence Collis, FSA director of communications, dismissed claims that the
proposals were not based on science. "We have some of the most respected
scientists in Europe, both within the FSA and in our independent advisory
committees. It is unjustified and nonsensical to attack the FSA’s scientific
reputation and to try to undermine its credibility."
9. The FSA is understood to have briefed its ad agency, United, before
Christmas, and will aim to air ads that are "non-confrontational, humorous and
factual" as a counterweight to industry’s efforts about the same time. The
agency, however, will have a tiny fraction of the budget available to the
industry.
10. Gavin Neath, chairman of Unilever UK and president of the Food and Drink
Federation, has said that the industry has made enormous progress but could not
accept red "stop" signs on its food.
11. Alastair Sykes, chief executive of Nestlé UK, said that under the FSA
proposals all his company’s confectionery and most of its cereals would score a
red. "Are we saying people shouldn’t eat confectionery? We’re driven by
consumers and what they want, and much of what we do has been to make our
products healthier," he said.
12. Chris Wermann, director of communications at Kellogg’s, said: "In
principle we could never accept traffic light labelling."
13. The rival labelling scheme introduced by Kellogg’s, Danone, Unilever,
Nestlé, Kraft and Tesco and now favoured by 21 manufacturers, uses an
industry-devised system based on identifying GDAs of key nutrients. Tesco says
it has tested both traffic lights and GDA labels in its stores and that the
latter increased sales of healthier foods.
14. But the FSA said it could not live with this GDA system alone because it
was "not scientific" or easy for shoppers to understand at a glance.
Questions 1-6
Answer the questions below using NO MORE THAN THREE WORDS from the passage
for each answer.
1. When will instructions be given on reading the color-coded labels?
2. Where can customers find the red light labels?
3. What problem is the FSA trying to handle with the labeling system?
4. Which product sells well but may not be healthy?
5. What information, according to the manufacturers, can be labeled on
products?
6. What can not be advertised during children’s programmes?
Questions 7-13
Use the information in the text to match the people (listed A-E) with the
opinions (listed 7-13) below. Write the appropriate letter (A-E) for questions
1-7.
NB You may use any letter more than once.
A Ed Richard
B Terrence Collis
C Gavin Neath
D Alastair Sykes
E Chris Wermann
7. Generally we will not agree to use the red light labels.
8. It is unreasonable to doubt if FSA is trustworthy.
9. We are trying to meet our consumers’ needs.
10. The food industry has been improving greatly.
11. The color-coded labeling system is scientific.
12. Our products will be labeled unhealthy by the FSA.
13. We are ready to confront the manufacturers.
