当前位置:考试网  > 试卷库  > 外语类  > 雅思  > 阅读  >  How shops can exploit people's herd mentality to increase sales 1.A TRIP to the supermarket may not seem like an exercise in psychological warfare—but it is.Shopkeepers know that filling a store with the aroma of freshly baked bread makes people feel hungry and persuades them to buy more food than they had intended.Stocking the most expensive products at eye level makes them sell faster than cheaper but less visible competitors.Now researchers are investigating how “swarm intelligence” (that is,how ants,bees or any social animal,including humans,behave in a crowd) can be used to influence what people buy. 2.At a recent conference on the simulation of adaptive behaviour in Rome,Zeeshan-ul-hassan Usmani,a computer scientist from the Florida Institute of Technology,described a new way to increase impulse buying using this phenomenon.Supermarkets already encourage shoppers to buy things they did not realise they wanted: for instance,by placing everyday items such as milk and eggs at the back of the store,forcing shoppers to walk past other tempting goods to reach them.Mr Usmani and Ronaldo Menezes,also of the Florida Institute of Technology,set out to enhance this tendency to buy more by playing on the herd instinct.The idea is that,if a certain product is seen to be popular,shoppers are likely to choose it too.The challenge is to keep customers informed about what others are buying. 3.Enter smart-cart technology.In Mr Usmani's supermarket every product has a radio frequency identification tag,a sort of barcode that uses radio waves to transmit information,and every trolley has a scanner that reads this information and relays it to a central computer.As a customer walks past a shelf of goods,a screen on the shelf tells him how many people currently in the shop have chosen that particular product.If the number is high,he is more likely to select it too. 4.Mr Usmani's “swarm-moves” model appeals to supermarkets because it increases sales without the need to give people discounts.And it gives shoppers the satisfaction of knowing that they bought the “right” product—that is,the one everyone else bought.The model has not yet been tested widely in the real world,mainly because radio frequency identification technology is new and has only been installed experimentally in some supermarkets.But Mr Usmani says that both Wal-Mart in America and Tesco in Britain are interested in his work,and testing will get under way in the spring. 5.Another recent study on the power of social influence indicates that sales could,indeed,be boosted in this way.Matthew Salganik of Columbia University in New York and his colleagues have described creating an artificial music market in which some 14,000 people downloaded previously unknown songs.The researchers found that when people could see the songs ranked by how many times they had been downloaded,they followed the crowd.When the songs were not ordered by rank,but the number of times they had been downloaded was displayed,the effect of social influence was still there but was less pronounced.People thus follow the herd when it is easy for them to do so. 6.In Japan a chain of convenience shops called RanKing RanQueen has been ordering its products according to sales data from department stores and research companies.The shops sell only the most popular items in each product category,and the rankings are updated weekly.Icosystem,a company in Cambridge,Massachusetts,also aims to exploit knowledge of social networking to improve sales. 7.And the psychology that works in physical stores is just as potent on the internet.Online retailers such as Amazon are adept at telling shoppers which products are popular with like-minded consumers.Even in the privacy of your home,you can still be part of the swarm. Questions 1-6 Complete the sentences below with words taken from the reading passage.Use NO MORE THAN THREE WORDS for each answer. 1.Shopowners realize that the smell of _______________ can increase sales of food products. 2.In shops,products shelved at a more visible level sell better even if they are more _______________. 3.According to Mr.Usmani,with the use of “swarm intelligence” phenomenon,a new method can be applied to encourage _______________. 4.On the way to everyday items at the back of the store,shoppers might be tempted to buy _______________. 5.If the number of buyers shown on the _______________ is high,other customers tend to follow them. 6.Using the “swarm-moves” model,shopowners do not have to give customers _______________ to increase sales.
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How shops can exploit people's herd mentality to increase sales

1.A TRIP to the supermarket may not seem like an exercise in psychological warfare—but it is.Shopkeepers know that filling a store with the aroma of freshly baked bread makes people feel hungry and persuades them to buy more food than they had intended.Stocking the most expensive products at eye level makes them sell faster than cheaper but less visible competitors.Now researchers are investigating how “swarm intelligence” (that is,how ants,bees or any social animal,including humans,behave in a crowd) can be used to influence what people buy.

2.At a recent conference on the simulation of adaptive behaviour in Rome,Zeeshan-ul-hassan Usmani,a computer scientist from the Florida Institute of Technology,described a new way to increase impulse buying using this phenomenon.Supermarkets already encourage shoppers to buy things they did not realise they wanted: for instance,by placing everyday items such as milk and eggs at the back of the store,forcing shoppers to walk past other tempting goods to reach them.Mr Usmani and Ronaldo Menezes,also of the Florida Institute of Technology,set out to enhance this tendency to buy more by playing on the herd instinct.The idea is that,if a certain product is seen to be popular,shoppers are likely to choose it too.The challenge is to keep customers informed about what others are buying.

3.Enter smart-cart technology.In Mr Usmani's supermarket every product has a radio frequency identification tag,a sort of barcode that uses radio waves to transmit information,and every trolley has a scanner that reads this information and relays it to a central computer.As a customer walks past a shelf of goods,a screen on the shelf tells him how many people currently in the shop have chosen that particular product.If the number is high,he is more likely to select it too.

4.Mr Usmani's “swarm-moves” model appeals to supermarkets because it increases sales without the need to give people discounts.And it gives shoppers the satisfaction of knowing that they bought the “right” product—that is,the one everyone else bought.The model has not yet been tested widely in the real world,mainly because radio frequency identification technology is new and has only been installed experimentally in some supermarkets.But Mr Usmani says that both Wal-Mart in America and Tesco in Britain are interested in his work,and testing will get under way in the spring.

5.Another recent study on the power of social influence indicates that sales could,indeed,be boosted in this way.Matthew Salganik of Columbia University in New York and his colleagues have described creating an artificial music market in which some 14,000 people downloaded previously unknown songs.The researchers found that when people could see the songs ranked by how many times they had been downloaded,they followed the crowd.When the songs were not ordered by rank,but the number of times they had been downloaded was displayed,the effect of social influence was still there but was less pronounced.People thus follow the herd when it is easy for them to do so.

6.In Japan a chain of convenience shops called RanKing RanQueen has been ordering its products according to sales data from department stores and research companies.The shops sell only the most popular items in each product category,and the rankings are updated weekly.Icosystem,a company in Cambridge,Massachusetts,also aims to exploit knowledge of social networking to improve sales.

7.And the psychology that works in physical stores is just as potent on the internet.Online retailers such as Amazon are adept at telling shoppers which products are popular with like-minded consumers.Even in the privacy of your home,you can still be part of the swarm.

Questions 1-6

Complete the sentences below with words taken from the reading passage.Use NO MORE THAN THREE WORDS for each answer.

1.Shopowners realize that the smell of _______________ can increase sales of food products.

2.In shops,products shelved at a more visible level sell better even if they are more _______________.

3.According to Mr.Usmani,with the use of “swarm intelligence” phenomenon,a new method can be applied to encourage _______________.

4.On the way to everyday items at the back of the store,shoppers might be tempted to buy _______________.

5.If the number of buyers shown on the _______________ is high,other customers tend to follow them.

6.Using the “swarm-moves” model,shopowners do not have to give customers _______________ to increase sales.

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正确答案:

1.答案:(freshly baked) bread.

2.答案:expensive.

3.答案:impulse buying.

4.答案:other (tempting) goods/things/products.

5.答案:screen.

6.答案:discounts.

答案解析:

1、(第1段第2行:Shoppersknowthatfillingastorewiththearomaoffreshlybakedbreadmakespeoplefeelhungryandpersuadesthemtobuymorefoodthantheyintended.)

2、(第1段第4行:Stockingthemostexpensiveproductsateyelevelmakesthemsellfasterthancheaperbutlessvisiblecompetitors.)

3、(第2段第1句:AtarecentconferenceonthesimulationofadaptivebehaviourinRome,Zeeshan-ul-hassanUsmani,acomputerscientistfromtheFloridaInstituteofTechnology,describedanewwaytoincreaseimpulsebuyingusingthisphenomenon.)

4、(第2段第2句:Supermarketsalreadyencourageshopperstobuythingstheydidnotrealisetheywanted:forinstance,byplacingeverydayitemssuchasmilkandeggsatthebackofthestore,forcingshopperstowalkpastothertemptinggoodstoreachthem.)

5、(第3段第4行:Asacustomerwalkspastashelfofgoods,ascreenontheshelftellshimhowmanypeoplecurrentlyintheshophavechosenthatparticularproduct.Ifthenumberishigh,heismorelikelytoselectittoo.)

6、(第4段第第1句:MrUsmani's“swarm-moves”modelappealstosupermarketsbecauseitincreasessaleswithouttheneedtogivepeoplediscounts.)

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To begin with,"muzak"(音乐广播网 )was intended simplyto createasoothing(安慰)atmosphere.Recently,however,it's ecome big business —thanks in part to recentresearch.Dr.Ronald Milliman,an American marketing expert,hasshown that music can boost sales or increase factory roduction by as much as a third.But,it has to be light music.A fast one has no effect atall on sales.Slow music can increase receipts by 38%.This isprobably because shoppers slow down and have more opportunityto spot items they like to buy.Yet,slow music isn't alway sanswer.Dr.Milliman found,for example,that in restaurants slowmusic meant customers took longer to eat their meals,whichreduced overall sales.So restaurants owners might be welladvised to play up-tempo music to keep the customers moving—unless of course,the resulting indigestion leads tocomplaints!

练习:

1.The reason why background music is so popular isthat ______.

A.it can have a powerful effect on those who hear it

B.it can help to create a soothing atmosphere

C.it can boost sales or increase factory production erywhere

D.it can make customers eat their meals quickly

2.Background music means ________.

A.light music that customers enjoy mostB.fast music that makes people move fast

C.slow music that can make customers enjoy their meals

D.the music you are listening to while you are doingomething

3.Restaurant owners complain about background musicbecause ______.

A.it results in indigestion

B.it increases their sales

C.it keeps customers moving

D.it decreases their sales

4.The word"up-tempo music"probably means_____.

A.slow music

B.fast music

C.light music

D.classical music

SellingDigitalMusicwithoutCopy-protectionMakesSense

A. Itwasuncharacteristicallylow-keyfortheindustry’sgreatestshowman.ButtheessaypublishedthisweekbySteveJobs,thebossofApple,onhisfirm’swebsiteundertheunassumingtitle“ThoughtsonMusic”hasnonethelessprovokedavigorousdebateaboutthefutureofdigitalmusic,whichAppledominateswithitsiPodmusic-playerandiTunesmusic-store.Atissueis“digitalrightsmanagement”(DRM)—thetechnologyguardingdownloadedmusicagainsttheft.SincethereisnocommonstandardforDRM,italsohastheside-effectthatsongspurchasedforonetypeofmusic-playermaynotworkonanother.Apple’sDRMsystem,calledFairPlay,isthemostwidespread.SoitcameasasurprisewhenMr.JobscalledforDRMfordigitalmusictobeabolished.

B. ThisisachangeoftackforApple.IthascomeunderfirefromEuropeanregulatorswhoclaimthatitsrefusaltolicenseFairPlaytootherfirmshas“lockedin”customers.SincemusicfromtheiTunesstorecannotbeplayedonnon-iPodmusic-players(atleastnotwithoutalotoffiddling),anyiTunesbuyerwillbedeterredfromswitchingtoadevicemadebyarivalfirm,suchasSonyorMicrosoft.WhenFrenchlawmakersdraftedabilllastyearcompellingAppletoopenupFairPlaytorivals,thecompanywarnedof“state-sponsoredpiracy”.OnlyDRM,itimplied,couldkeepthepiratesatbay.

C. ThisweekMr.JobsgaveanotherexplanationforhisformerdefenceofDRM:therecordcompaniesmadehimdoit.TheywouldmaketheirmusicavailabletotheiTunesstoreonlyifAppleagreedtoprotectitusingDRM.TheycanstillwithdrawtheircataloguesiftheDRMsystemiscompromised.ApplecannotlicenseFairPlaytoothers,saysMrJobs,becauseitwoulddependonthemtoproducesecurityfixespromptly.AllDRMdoesisrestrictconsumerchoiceandprovideabarriertoentry,saysMrJobs;withoutittherewouldbefarmorestoresandplayers,andfarmoreinnovation.So,hesuggests,whynotdoawaywithDRMandsellmusicunprotected?“Thisisclearlythebestalternativeforconsumers,”hedeclares,“andApplewouldembraceitinaheartbeat.”

D. Whythesuddenchangeofheart?MrJobsseemschieflyconcernedwithgettingEurope’sregulatorsoffhisback.RatherthancomplainingtoAppleaboutitsuseofDRM,hesuggests,“thoseunhappywiththecurrentsituationshouldredirecttheirenergiestowardspersuadingthemusiccompaniestoselltheirmusicDRM-free.”Twoandahalfofthefourbigrecordcompanies,hehelpfullypointsout,areEuropean-owned.MrJobsalsohopestopainthimselfasaconsumerchampion.AppleresentsaccusationsthatithasbecometheMicrosoftofdigitalmusic.

E. Applecanaffordtoembraceopencompetitioninmusicplayersandonlinestores.Consumerswouldgravitatetothebestplayerandthebeststore,andatthemomentthatstillmeansApple’s.MrJobsisevidentlyunfazedbyrivalstotheiPod.Sinceonly3%ofthemusicinatypicaliTuneslibraryisprotected,mostofitcanalreadybeusedonotherplayerstoday,henotes.(AndeventheprotectedtrackscanbeburnedontoaCDandthenre-ripped.)SoApple’sdominanceevidentlydependsfarmoreonbrandingandeaseofusethanDRM-related“lockin”.

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NotestoReadingPassage1

1.low-key:

抑制的,受约束的,屈服的

2.showman:

开展览会的人,出风头的人物

3.unassuming:

谦逊的,不夸耀的,不装腔作势的

4.iPod:

(苹果公司出产的)音乐播放器

5.iTunesstore:

(苹果公司出产的)在线音乐商店

6.getoffperson’sback:

不再找某人的麻烦,摆脱某人的纠缠

7.gravitate:

受吸引,倾向于

8.unfazed:

不再担忧,不被打扰

Questions1-7

DothefollowingstatemetsreflecttheclaimsofthewriterinReadingPassage1?

WriteyouranswerinBoxes1-7onyouranswersheet.

TRUEifthestatementrefletstheclaimsofthewriter

FALSEifthestatementcontradictstheclaimsofthewriter

NOTGIVENifitisimpossbiletosaywhatthewriterthinksaboutthis

1.AppleenjoysacontrollingpositionindigitalmusicmarketwithitsiPodmusic-playerandiTunesmusic-store.

2.DRMisagovernmentdecreeissuedwithapurposetoprotectdownloadedmusicfromtheftbyconsumers.

3.LackofstandardizationinDRMmakessongsboughtforonekindofmusicplayermaynotfunctiononanother.

4.ApplehasbeencriticizedbyEuropeanregulatorssinceithasrefusedtograntalicenseFairPlaytootherfirms.

5.Allmusiccanbeeasilyplayedonnon-iPodmusicdevicesfromSonyorMicrosoftwithouttoomuchfiddling.

6.AppledependsfarmoreonDRMratherthanbrandingforitsdominanceofthedigitalmusicdevices.

7.IfDRMwascancelled,Sonywouldcertainlydominatetheinternationaldigitalmusicmarket.

Questions8-10

ChoosetheappropriatelettersA-Dandwritetheminboxes8-10onyouranswesheet.

8.WhichofthefollowingstatementsaboutMr.Jobs’ideaofDRMisNOTTRUE?

A.DRMplacesrestrictionsonconsumer’choiceofdigitalmusicproductsavailable.

B.DRMcomplesiTunesbuyerstoswitchtoadevicemadebySonyorMicrosoft.

C.DRMconstitutesabarrierforpotentialconsumerstoenterdigitalmusicmarkets.

D.DRMhindersdevelopmentofmorestoresandplayersandtechnicalinnovation.

9.Theword“unfazed”inline3ofparagraphE,means___________.

A.refused

B.welcomed

C.notbothered

D.notwellreceived

10.WhichofthefollowingstatementsisTRUEifDRMwasscapped?

A.Sonywouldgainthemostprofit.

B.Morecustomerswouldbe“lockedin”.

C.Asuddenincreaseinpiracywouldoccur.

D.Online-musicsaleswouldprobablydecrease.

Questions11-14

Completethenotesbelow.

ChooseNOMORETHANTHREEWORDSfromReadingPassage1foreachanswer.

Writeyouranswersinboxes11-14onyouranswersheet.

Mr.SteveJobs,thebossofApple,explainsthereasonwhyheusedtodefendDRM,sayingthatthecompanywasforcedtodoso:therecordcompanieswouldmaketheirmusicaccessibleto…11...onlyiftheyagreedtoprotectitusingDRM;theycanstill…12…iftheDRMsystemiscompromised.HealsoprovidesthereasonwhyAppledidnotlicenseFairPlaytoothers:thecompanyreliesonthemto…13….ButnowhechangeshismindwithapossibleexpectationthatEurope’sregulatorswouldnottroublehimanymoreinthefuture.Heproposesthatthosewhoareunsatisfactorywiththecurrentsituationindigitalmusicmarketshould…14…towardspersuadethemusiccompaniestoselltheirmusicDRM-free.

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Questions7-13

Matchtorcetrapib,HDLs,statinandCETPwiththeirfunctions(Questions8-13)..WritethecorrectletterA,B,CorDinboxes8-13onyouranswersheet.NBYoumayuseanylettermorethanonce.

7.Ithasbeenadministeredtoover10,000subjectsinaclinicaltrial.

8.Itcouldhelpridhumanbodyofcholesterol.

9.Researchersareyettofindmoreaboutit.

10.Itwasusedtoreducethelevelofcholesterol.

11.AccordingtoKashyap,itmightleadtounwantedresultifit'sblocked.

12.Itproducedcontradictoryresultsindifferenttrials.

13.ItcouldinhibitLDLs.Listofchoices

A.TorcetrapicB.HDLSC.StatinD.CETP

1 There's a dimmer switch inside the sun that causes its brightness to rise and fall on timescales of around 100,000 years - exactly the same period as between ice ages on Earth. So says a physicist who has created a computer model of our star's core.

2 Robert Ehrlich of George Mason University in Fairfax, Virginia, modelled the effect of temperature fluctuations in the sun's interior. According to the standard view, the temperature of the sun's core is held constant by the opposing pressures of gravity and nuclear fusion. However, Ehrlich believed that slight variations should be possible.

3 He took as his starting point the work of Attila Grandpierre of the Konkoly Observatory of the Hungarian Academy of Sciences. In 2005, Grandpierre and a collaborator, Gábor ágoston, calculated that magnetic fields in the sun's core could produce small instabilities in the solar plasma. These instabilities would induce localised oscillations in temperature.

4 Ehrlich's model shows that whilst most of these oscillations cancel each other out, some reinforce one another and become long-lived temperature variations. The favoured frequencies allow the sun's core temperature to oscillate around its average temperature of 13.6 million kelvin in cycles lasting either 100,000 or 41,000 years. Ehrlich says that random interactions within the sun's magnetic field could flip the fluctuations from one cycle length to the other.

5 These two timescales are instantly recognisable to anyone familiar with Earth's ice ages: for the past million years, ice ages have occurred roughly every 100,000 years. Before that, they occurred roughly every 41,000 years.

6 Most scientists believe that the ice ages are the result of subtle changes in Earth's orbit, known as the Milankovitch cycles. One such cycle describes the way Earth's orbit gradually changes shape from a circle to a slight ellipse and back again roughly every 100,000 years. The theory says this alters the amount of solar radiation that Earth receives, triggering the ice ages. However, a persistent problem with this theory has been its inability to explain why the ice ages changed frequency a million years ago.

7 "In Milankovitch, there is certainly no good idea why the frequency should change from one to another," says Neil Edwards, a climatologist at the Open University in Milton Keynes, UK. Nor is the transition problem the only one the Milankovitch theory faces. Ehrlich and other critics claim that the temperature variations caused by Milankovitch cycles are simply not big enough to drive ice ages.

8 However, Edwards believes the small changes in solar heating produced by Milankovitch cycles are then amplified by feedback mechanisms on Earth. For example, if sea ice begins to form because of a slight cooling, carbon dioxide that would otherwise have found its way into the atmosphere as part of the carbon cycle is locked into the ice. That weakens the greenhouse effect and Earth grows even colder.

9 According to Edwards, there is no lack of such mechanisms. "If you add their effects together, there is more than enough feedback to make Milankovitch work," he says. "The problem now is identifying which mechanisms are at work." This is why scientists like Edwards are not yet ready to give up on the current theory. "Milankovitch cycles give us ice ages roughly when we observe them to happen. We can calculate where we are in the cycle and compare it with observation," he says. "I can't see any way of testing [Ehrlich's] idea to see where we are in the temperature oscillation."

10 Ehrlich concedes this. "If there is a way to test this theory on the sun, I can't think of one that is practical," he says. That's because variation over 41,000 to 100,000 years is too gradual to be observed. However, there may be a way to test it in other stars: red dwarfs. Their cores are much smaller than that of the sun, and so Ehrlich believes that the oscillation periods could be short enough to be observed. He has yet to calculate the precise period or the extent of variation in brightness to be expected.

11 Nigel Weiss, a solar physicist at the University of Cambridge, is far from convinced. He describes Ehrlich's claims as "utterly implausible". Ehrlich counters that Weiss's opinion is based on the standard solar model, which fails to take into account the magnetic instabilities that cause the temperature fluctuations.

Questions 1-4

Complete each of the following statements with One or Two names of the scientists from the box below.

Write the appropriate letters A-E in boxes 1-4 on your answer sheet.

A. Attila Grandpierre

B. Gábor ágoston

C. Neil Edwards

D. Nigel Weiss

E. Robert Ehrlich

1. ...claims there a dimmer switch inside the sun that causes its brightness to rise and fall in periods as long as those between ice ages on Earth.

2. ...calculated that the internal solar magnetic fields could produce instabilities in the solar plasma.

3. ...holds that Milankovitch cycles can induce changes in solar heating on Earth and the changes are amplified on Earth.

4. ...doesn't believe in Ehrlich's viewpoints at all.

Questions 5-9

Do the following statements agree with the information given in the reading passage?

In boxes 5-9 on your answer sheet write

TRUE if the statement is true according to the passage

FALSE if the statement is false according to the passage

NOT GIVEN if the information is not given in the passage

5. The ice ages changed frequency from 100,000 to 41,000 years a million years ago.

6. The sole problem that the Milankovitch theory can not solve is to explain why the ice age frequency should shift from one to another.

7. Carbon dioxide can be locked artificially into sea ice to eliminate the greenhouse effect.

8. Some scientists are not ready to give up the Milankovitch theory though they haven't figured out which mechanisms amplify the changes in solar heating.

9. Both Edwards and Ehrlich believe that there is no practical way to test when the solar temperature oscillation begins and when ends.

Questions 10-14

Complete the notes below.

Choose one suitable word from the Reading Passage above for each answer.

Write your answers in boxes 10-14 on your answer sheet.

The standard view assumes that the opposing pressures of gravity and nuclear fusions hold the temperature ...10...in the sun's interior, but the slight changes in the earth's ...11... alter the temperature on the earth and cause ice ages every 100,000 years. A British scientist, however, challenges this view by claiming that the internal solar magnetic ...12... can induce the temperature oscillations in the sun's interior. The sun's core temperature oscillates around its average temperature in ...13... lasting either 100,000 or 41,000 years. And the ...14... interactions within the sun's magnetic field could flip the fluctuations from one cycle length to the other, which explains why the ice ages changed frequency a million years ago.

1.The failure of a high-profile cholesterol drug has thrown a spotlight on the complicated machinery that regulates cholesterol levels.But many researchers remain confident that drugs to boost levels of 'good' cholesterol are still one of the most promising means to combat spiralling heart disease.

2.Drug company Pfizer announced on 2 December that it was cancelling all clinical trials of torcetrapib,a drug designed to raise heart-protective high-density lipoproteins (HDLs).In a trial of 15000 patients,a safety board found that more people died or suffered cardiovascular problems after taking the drug plus a cholesterol-lowering statin than those in a control group who took the statin alone.

3.The news came as a kick in the teeth to many cardiologists because earlier tests in animals and people suggested it would lower rates of cardiovascular disease."There have been no red flags to my knowledge," says John Chapman,a specialist in lipoproteins and atherosclerosis at the National Institute for Health and Medical Research (INSERM) in Paris who has also studied torcetrapib."This cancellation came as a complete shock."

4.Torcetrapib is one of the most advanced of a new breed of drugs designed to raise levels of HDLs,which ferry cholesterol out of artery-clogging plaques to the liver for removal from the body.Specifically,torcetrapib blocks a protein called cholesterol ester transfer protein (CETP),which normally transfers the cholesterol from high-density lipoproteins to low density,plaque-promoting ones.Statins,in contrast,mainly work by lowering the 'bad' low-density lipoproteins.

Under pressure

5.Researchers are now trying to work out why and how the drug backfired,something that will not become clear until the clinical details are released by Pfizer.One hint lies in evidence from earlier trials that it slightly raises blood pressure in some patients.It was thought that this mild problem would be offset by the heart benefits of the drug.But it is possible that it actually proved fatal in some patients who already suffered high blood pressure.If blood pressure is the explanation,it would actually be good news for drug developers because it suggests that the problems are specific to this compound.Other prototype drugs that are being developed to block CETP work in a slightly different way and might not suffer the same downfall.

6.But it is also possible that the whole idea of blocking CETP is flawed,says Moti Kashyap,who directs atherosclerosis research at the VA Medical Center in Long Beach,California.When HDLs excrete cholesterol in the liver,they actually rely on LDLs for part of this process.So inhibiting CETP,which prevents the transfer of cholesterol from HDL to LDL,might actually cause an abnormal and irreversible accumulation of cholesterol in the body."You're blocking a physiologic mechanism to eliminate cholesterol and effectively constipating the pathway," says Kashyap.Going up

7.Most researchers remain confident that elevating high density lipoproteins levels by one means or another is one of the best routes for helping heart disease patients.But HDLs are complex and not entirely understood.One approved drug,called niacin,is known to both raise HDL and reduce cardiovascular risk but also causes an unpleasant sensation of heat and tingling.Researchers are exploring whether they can bypass this side effect and whether niacin can lower disease risk more than statins alone.Scientists are also working on several other means to bump up high-density lipoproteins by,for example,introducing synthetic HDLs."The only thing we know is dead in the water is torcetrapib,not the whole idea of raising HDL," says Michael Miller,director of preventive cardiology at the University of Maryland Medical Center,Baltimore.

Questions 7-13

Match torcetrapib,HDLs,statin and CETP with their functions (Questions 8-13)..Write the correct letter A,B,C or D in boxes 8-13 on your answer sheet.NB You may use any letter more than once.

7.It has been administered to over 10,000 subjects in a clinical trial.

8.It could help rid human body of cholesterol.

9.Researchers are yet to find more about it.

10.It was used to reduce the level of cholesterol.

11.According to Kashyap,it might lead to unwanted result if it's blocked.

12.It produced contradictory results in different trials.

13.It could inhibit LDLs.List of choices

A.TorcetrapicB.HDLSC.StatinD.CETP

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