1.Thefailureofahigh-profilecholesteroldrughasthrownaspotlightonthecomplicatedmachinerythatregulatescholesterollevels.Butmanyresearchersremainconfidentthatdrugstoboostlevelsof'good'cholesterolarestilloneofthemostpromisingmeanstocombatspirallingheartdisease.
2.DrugcompanyPfizerannouncedon2Decemberthatitwascancellingallclinicaltrialsoftorcetrapib,adrugdesignedtoraiseheart-protectivehigh-densitylipoproteins(HDLs).Inatrialof15000patients,asafetyboardfoundthatmorepeoplediedorsufferedcardiovascularproblemsaftertakingthedrugplusacholesterol-loweringstatinthanthoseinacontrolgroupwhotookthestatinalone.
3.Thenewscameasakickintheteethtomanycardiologistsbecauseearliertestsinanimalsandpeoplesuggesteditwouldlowerratesofcardiovasculardisease."Therehavebeennoredflagstomyknowledge,"saysJohnChapman,aspecialistinlipoproteinsandatherosclerosisattheNationalInstituteforHealthandMedicalResearch(INSERM)inPariswhohasalsostudiedtorcetrapib."Thiscancellationcameasacompleteshock."
4.TorcetrapibisoneofthemostadvancedofanewbreedofdrugsdesignedtoraiselevelsofHDLs,whichferrycholesteroloutofartery-cloggingplaquestotheliverforremovalfromthebody.Specifically,torcetrapibblocksaproteincalledcholesterolestertransferprotein(CETP),whichnormallytransfersthecholesterolfromhigh-densitylipoproteinstolowdensity,plaque-promotingones.Statins,incontrast,mainlyworkbyloweringthe'bad'low-densitylipoproteins.
Underpressure
5.Researchersarenowtryingtoworkoutwhyandhowthedrugbackfired,somethingthatwillnotbecomeclearuntiltheclinicaldetailsarereleasedbyPfizer.Onehintliesinevidencefromearliertrialsthatitslightlyraisesbloodpressureinsomepatients.Itwasthoughtthatthismildproblemwouldbeoffsetbytheheartbenefitsofthedrug.Butitispossiblethatitactuallyprovedfatalinsomepatientswhoalreadysufferedhighbloodpressure.Ifbloodpressureistheexplanation,itwouldactuallybegoodnewsfordrugdevelopersbecauseitsuggeststhattheproblemsarespecifictothiscompound.OtherprototypedrugsthatarebeingdevelopedtoblockCETPworkinaslightlydifferentwayandmightnotsufferthesamedownfall.
6.ButitisalsopossiblethatthewholeideaofblockingCETPisflawed,saysMotiKashyap,whodirectsatherosclerosisresearchattheVAMedicalCenterinLongBeach,California.WhenHDLsexcretecholesterolintheliver,theyactuallyrelyonLDLsforpartofthisprocess.SoinhibitingCETP,whichpreventsthetransferofcholesterolfromHDLtoLDL,mightactuallycauseanabnormalandirreversibleaccumulationofcholesterolinthebody."You'reblockingaphysiologicmechanismtoeliminatecholesterolandeffectivelyconstipatingthepathway,"saysKashyap.Goingup
7.Mostresearchersremainconfidentthatelevatinghighdensitylipoproteinslevelsbyonemeansoranotherisoneofthebestroutesforhelpingheartdiseasepatients.ButHDLsarecomplexandnotentirelyunderstood.Oneapproveddrug,calledniacin,isknowntobothraiseHDLandreducecardiovascularriskbutalsocausesanunpleasantsensationofheatandtingling.Researchersareexploringwhethertheycanbypassthissideeffectandwhetherniacincanlowerdiseaseriskmorethanstatinsalone.Scientistsarealsoworkingonseveralothermeanstobumpuphigh-densitylipoproteinsby,forexample,introducingsyntheticHDLs."Theonlythingweknowisdeadinthewateristorcetrapib,notthewholeideaofraisingHDL,"saysMichaelMiller,directorofpreventivecardiologyattheUniversityofMarylandMedicalCenter,Baltimore.
Questions7-13
Matchtorcetrapib,HDLs,statinandCETPwiththeirfunctions(Questions8-13)..WritethecorrectletterA,B,CorDinboxes8-13onyouranswersheet.NBYoumayuseanylettermorethanonce.
7.Ithasbeenadministeredtoover10,000subjectsinaclinicaltrial.
8.Itcouldhelpridhumanbodyofcholesterol.
9.Researchersareyettofindmoreaboutit.
10.Itwasusedtoreducethelevelofcholesterol.
11.AccordingtoKashyap,itmightleadtounwantedresultifit'sblocked.
12.Itproducedcontradictoryresultsindifferenttrials.
13.ItcouldinhibitLDLs.Listofchoices
A.TorcetrapicB.HDLSC.StatinD.CETP
7.A
8.B
9.B
10.C
11.D
12.A
13.C
暂无解析
1.AEuropeanspacecrafttookofftodaytospearheadthesearchforanother"Earth"amongthestars.
2.TheCorotspacetelescopeblastedoffaboardaRussianSoyuzrocketfromtheBaikonurcosmodromeinKazakhstanshortlyafter2.20pm.
3.Corot,shortforconvectionrotationandplanetarytransits,isthefirstinstrumentcapableoffindingsmallrockyplanetsbeyondthesolarsystem.Anysuchplanetsituatedintherightorbitstandsagoodchanceofhavingliquidwateronitssurface,andquitepossiblylife,althoughaleadingscientistinvolvedintheprojectsaiditwasunlikelytofind"anylittlegreenmen".
4.DevelopedbytheFrenchspaceagency,CNES,andpartneredbytheEuropeanSpaceAgency(ESA),Austria,Belgium,Germany,BrazilandSpain,Corotwillmonitoraround120,000starswithits27cmtelescopefromapolarorbit514milesabovetheEarth.Overtwoandahalfyears,itwillfocusonfivetosixdifferentareasofthesky,measuringthebrightnessofabout10,000starsevery512seconds.
5."Atthepresentmomentwearehopingtofindoutmoreaboutthenatureofplanetsaroundstarswhicharepotentialhabitats.Wearelookingathabitableplanets,notinhabitedplanets.Wearenotgoingtofindanylittlegreenmen,"ProfessorIanRoxburgh,anESAscientistwhohasbeeninvolvedwithCorotsinceitsinception,toldtheBBCRadio4Todayprogramme.
6.ProfRoxburghsaiditwashopedCorotwouldfind"rockyplanetsthatcoulddevelopanatmosphereand,iftheyaretherightdistancefromtheirparentstar,theycouldhavewater".
7.Tosearchforplanets,thetelescopewilllookforthedimmingofstarlightcausedwhenanobjectpassesinfrontofastar,knownasa"transit".Althoughitwilltakemoresophisticatedspacetelescopesplannedinthenext10yearstoconfirmthepresenceofanEarth-likeplanetwithoxygenandliquidwater,Corotwillletscientistsknowwheretopointtheirlenses.
8.MeasurementsofminutechangesinbrightnesswillenablescientiststodetectgiantJupiter-likegasplanetsaswellassmallrockyones.Itistherockyplanets-thatcouldbenobiggerthanabouttwicethesizeoftheEarth-whichwillcausethemostexcitement.Scientistsexpecttofindbetween10and40ofthesesmallerplanets.
9.Corotwillalsoprobeintostellarinteriorsbystudyingtheacousticwavesthatrippleacrossthesurfaceofstars,atechniquecalled"asteroseismology".
10.Thenatureoftheripplesallowsastronomerstocalculateastar’sprecisemass,ageandchemicalcomposition.
11."Aplanetpassinginfrontofastarcanbedetectedbythefallinlightfromthatstar.Smalloscillationsofthestaralsoproducechangesinthelightemitted,whichrevealwhatthestarismadeofandhowtheyarestructuredinternally.Thisdatawillprovideamajorboosttoourunderstandingofhowstarsformandevolve,"ProfRoxburghsaid.
12.Sincethediscoveryin1995ofthefirst"exoplanet"-aplanetorbitingastarotherthantheSun-morethan200othershavebeenfoundbyground-basedobservatories.
13.Untilnowtheusualmethodoffindingexoplanetshasbeentodetectthe"wobble"theirgravityimpartsonparentstars.ButonlygiantgaseousplanetsbiggerthanJupitercanbefoundthisway,andtheyareunlikelytoharbourlife.
14.Inthe2010s,ESAplanstolaunchDarwin,afleetoffourorfiveinterlinkedspacetelescopesthatwillnotonlyspotsmallrockyplanets,butanalysetheiratmospheresforsignsofbiologicalactivity.
15.Ataroundthesametime,theUSspaceagency,Nasa,willlaunchTerrestrialPlanetFinder,anotherspacetelescopedesignedtolocateEarth-likeplanets.
ChoosetheappropriateletterfromA-Dforquestion1.
1.Corotisaninstrumentwhich
(A)canhelptosearchforcertainplanets
(B)isusedtofindplanetsintheorbit
(C)canlocateplanetswithhumanbeings
(D)canspotanyplanetswithwater.
Dothefollowingstatementsagreewiththeinformationgiveninthereadingpassage?Forquestions2-5write
TRUEifthestatementagreeswiththeinformation
FALSEifthestatementcontraictstheinformation
NOTGIVENifthereisnoinformationonthisinthepassage
2.Scientistsaretryingtofindoutabouttheplanetsthatcanbeinhabited.
3.BBCRadio4recentlyfocusesonthebroadcastingofCorot.
4.Passingobjectsmightcauseafallinlight.
5.CorotcantellwhetherthereisanotherEarth-likeplanet.
Basedonyourreadingofthepassage,completethesentencesbelowwithwordstakenfromthepassage.UseNOMORETHANTHREEWORDSforeachanswer.
Withmeasurements,scientistswillbeabletosearchforsomegaseousandrockyplanets.Theywillbeextremelyexcitediftheycandiscoversomesmall6.__________,theexpectednumberofwhichcouldbeupto7.__________.
Corotwillenablescientiststostudythe8.__________ofstars.Inthisway,astar’smass,ageandchemicalcompositioncanbecalculated.
AccordingtoProfRoxburgh,changesinlightcanbecausedbypassingplanetsorstar9.__________.Therelatedstatisticscangainusabetter10.__________ofthestarformationandevolvement.
Observatorieshavefoundmanyexoplanets,whichare11.__________otherstarsthantheSun.Thecommonwayusedinfindingexoplanetscanonlydetecthugegasplanets,whichdonot12.___________.
WiththelaunchingofDarwin,astronomerswillbeabletoanalysewhetherthoserockyplanetshave13.__________forlife.
1.Thefailureofahigh-profilecholesteroldrughasthrownaspotlightonthecomplicatedmachinerythatregulatescholesterollevels.Butmanyresearchersremainconfidentthatdrugstoboostlevelsof'good'cholesterolarestilloneofthemostpromisingmeanstocombatspirallingheartdisease.
2.DrugcompanyPfizerannouncedon2Decemberthatitwascancellingallclinicaltrialsoftorcetrapib,adrugdesignedtoraiseheart-protectivehigh-densitylipoproteins(HDLs).Inatrialof15000patients,asafetyboardfoundthatmorepeoplediedorsufferedcardiovascularproblemsaftertakingthedrugplusacholesterol-loweringstatinthanthoseinacontrolgroupwhotookthestatinalone.
3.Thenewscameasakickintheteethtomanycardiologistsbecauseearliertestsinanimalsandpeoplesuggesteditwouldlowerratesofcardiovasculardisease."Therehavebeennoredflagstomyknowledge,"saysJohnChapman,aspecialistinlipoproteinsandatherosclerosisattheNationalInstituteforHealthandMedicalResearch(INSERM)inPariswhohasalsostudiedtorcetrapib."Thiscancellationcameasacompleteshock."
4.TorcetrapibisoneofthemostadvancedofanewbreedofdrugsdesignedtoraiselevelsofHDLs,whichferrycholesteroloutofartery-cloggingplaquestotheliverforremovalfromthebody.Specifically,torcetrapibblocksaproteincalledcholesterolestertransferprotein(CETP),whichnormallytransfersthecholesterolfromhigh-densitylipoproteinstolowdensity,plaque-promotingones.Statins,incontrast,mainlyworkbyloweringthe'bad'low-densitylipoproteins.
Underpressure
5.Researchersarenowtryingtoworkoutwhyandhowthedrugbackfired,somethingthatwillnotbecomeclearuntiltheclinicaldetailsarereleasedbyPfizer.Onehintliesinevidencefromearliertrialsthatitslightlyraisesbloodpressureinsomepatients.Itwasthoughtthatthismildproblemwouldbeoffsetbytheheartbenefitsofthedrug.Butitispossiblethatitactuallyprovedfatalinsomepatientswhoalreadysufferedhighbloodpressure.Ifbloodpressureistheexplanation,itwouldactuallybegoodnewsfordrugdevelopersbecauseitsuggeststhattheproblemsarespecifictothiscompound.OtherprototypedrugsthatarebeingdevelopedtoblockCETPworkinaslightlydifferentwayandmightnotsufferthesamedownfall.
6.ButitisalsopossiblethatthewholeideaofblockingCETPisflawed,saysMotiKashyap,whodirectsatherosclerosisresearchattheVAMedicalCenterinLongBeach,California.WhenHDLsexcretecholesterolintheliver,theyactuallyrelyonLDLsforpartofthisprocess.SoinhibitingCETP,whichpreventsthetransferofcholesterolfromHDLtoLDL,mightactuallycauseanabnormalandirreversibleaccumulationofcholesterolinthebody."You'reblockingaphysiologicmechanismtoeliminatecholesterolandeffectivelyconstipatingthepathway,"saysKashyap.Goingup
7.Mostresearchersremainconfidentthatelevatinghighdensitylipoproteinslevelsbyonemeansoranotherisoneofthebestroutesforhelpingheartdiseasepatients.ButHDLsarecomplexandnotentirelyunderstood.Oneapproveddrug,calledniacin,isknowntobothraiseHDLandreducecardiovascularriskbutalsocausesanunpleasantsensationofheatandtingling.Researchersareexploringwhethertheycanbypassthissideeffectandwhetherniacincanlowerdiseaseriskmorethanstatinsalone.Scientistsarealsoworkingonseveralothermeanstobumpuphigh-densitylipoproteinsby,forexample,introducingsyntheticHDLs."Theonlythingweknowisdeadinthewateristorcetrapib,notthewholeideaofraisingHDL,"saysMichaelMiller,directorofpreventivecardiologyattheUniversityofMarylandMedicalCenter,Baltimore.
Questions7-13
Matchtorcetrapib,HDLs,statinandCETPwiththeirfunctions(Questions8-13)..WritethecorrectletterA,B,CorDinboxes8-13onyouranswersheet.NBYoumayuseanylettermorethanonce.
7.Ithasbeenadministeredtoover10,000subjectsinaclinicaltrial.
8.Itcouldhelpridhumanbodyofcholesterol.
9.Researchersareyettofindmoreaboutit.
10.Itwasusedtoreducethelevelofcholesterol.
11.AccordingtoKashyap,itmightleadtounwantedresultifit'sblocked.
12.Itproducedcontradictoryresultsindifferenttrials.
13.ItcouldinhibitLDLs.Listofchoices
A.TorcetrapicB.HDLSC.StatinD.CETP
SellingDigitalMusicwithoutCopy-protectionMakesSense
A. Itwasuncharacteristicallylow-keyfortheindustry’sgreatestshowman.ButtheessaypublishedthisweekbySteveJobs,thebossofApple,onhisfirm’swebsiteundertheunassumingtitle“ThoughtsonMusic”hasnonethelessprovokedavigorousdebateaboutthefutureofdigitalmusic,whichAppledominateswithitsiPodmusic-playerandiTunesmusic-store.Atissueis“digitalrightsmanagement”(DRM)—thetechnologyguardingdownloadedmusicagainsttheft.SincethereisnocommonstandardforDRM,italsohastheside-effectthatsongspurchasedforonetypeofmusic-playermaynotworkonanother.Apple’sDRMsystem,calledFairPlay,isthemostwidespread.SoitcameasasurprisewhenMr.JobscalledforDRMfordigitalmusictobeabolished.
B. ThisisachangeoftackforApple.IthascomeunderfirefromEuropeanregulatorswhoclaimthatitsrefusaltolicenseFairPlaytootherfirmshas“lockedin”customers.SincemusicfromtheiTunesstorecannotbeplayedonnon-iPodmusic-players(atleastnotwithoutalotoffiddling),anyiTunesbuyerwillbedeterredfromswitchingtoadevicemadebyarivalfirm,suchasSonyorMicrosoft.WhenFrenchlawmakersdraftedabilllastyearcompellingAppletoopenupFairPlaytorivals,thecompanywarnedof“state-sponsoredpiracy”.OnlyDRM,itimplied,couldkeepthepiratesatbay.
C. ThisweekMr.JobsgaveanotherexplanationforhisformerdefenceofDRM:therecordcompaniesmadehimdoit.TheywouldmaketheirmusicavailabletotheiTunesstoreonlyifAppleagreedtoprotectitusingDRM.TheycanstillwithdrawtheircataloguesiftheDRMsystemiscompromised.ApplecannotlicenseFairPlaytoothers,saysMrJobs,becauseitwoulddependonthemtoproducesecurityfixespromptly.AllDRMdoesisrestrictconsumerchoiceandprovideabarriertoentry,saysMrJobs;withoutittherewouldbefarmorestoresandplayers,andfarmoreinnovation.So,hesuggests,whynotdoawaywithDRMandsellmusicunprotected?“Thisisclearlythebestalternativeforconsumers,”hedeclares,“andApplewouldembraceitinaheartbeat.”
D. Whythesuddenchangeofheart?MrJobsseemschieflyconcernedwithgettingEurope’sregulatorsoffhisback.RatherthancomplainingtoAppleaboutitsuseofDRM,hesuggests,“thoseunhappywiththecurrentsituationshouldredirecttheirenergiestowardspersuadingthemusiccompaniestoselltheirmusicDRM-free.”Twoandahalfofthefourbigrecordcompanies,hehelpfullypointsout,areEuropean-owned.MrJobsalsohopestopainthimselfasaconsumerchampion.AppleresentsaccusationsthatithasbecometheMicrosoftofdigitalmusic.
E. Applecanaffordtoembraceopencompetitioninmusicplayersandonlinestores.Consumerswouldgravitatetothebestplayerandthebeststore,andatthemomentthatstillmeansApple’s.MrJobsisevidentlyunfazedbyrivalstotheiPod.Sinceonly3%ofthemusicinatypicaliTuneslibraryisprotected,mostofitcanalreadybeusedonotherplayerstoday,henotes.(AndeventheprotectedtrackscanbeburnedontoaCDandthenre-ripped.)SoApple’sdominanceevidentlydependsfarmoreonbrandingandeaseofusethanDRM-related“lockin”.
F. ThemusicgiantsaretryingDRM-freedownloads.Lotsofsmallerlabelsalreadysellmusicthatway.Havingseenwhichwaythewindisblowing,MrJobsnowwantstobeseennotasDRM’sdefender,butasaconsumerchampionwhohelpedinitsdownfall.Wouldn’titleadtoasurgeinpiracy?No,becausemostmusicisstillsoldunprotectedonCDs,peoplewishingtostealmusicalreadycandoso.Indeed,scrappingDRMwouldprobablyincreaseonline-musicsalesbyreducingconfusionandincompatibility.Withtheleadingonlinestore,Applewouldbenefitmost.MrJobs’sargument,inshort,istransparentlyself-serving.Italsohappenstoberight.
NotestoReadingPassage1
1.low-key:
抑制的,受约束的,屈服的
2.showman:
开展览会的人,出风头的人物
3.unassuming:
谦逊的,不夸耀的,不装腔作势的
4.iPod:
(苹果公司出产的)音乐播放器
5.iTunesstore:
(苹果公司出产的)在线音乐商店
6.getoffperson’sback:
不再找某人的麻烦,摆脱某人的纠缠
7.gravitate:
受吸引,倾向于
8.unfazed:
不再担忧,不被打扰
Questions1-7
DothefollowingstatemetsreflecttheclaimsofthewriterinReadingPassage1?
WriteyouranswerinBoxes1-7onyouranswersheet.
TRUEifthestatementrefletstheclaimsofthewriter
FALSEifthestatementcontradictstheclaimsofthewriter
NOTGIVENifitisimpossbiletosaywhatthewriterthinksaboutthis
1.AppleenjoysacontrollingpositionindigitalmusicmarketwithitsiPodmusic-playerandiTunesmusic-store.
2.DRMisagovernmentdecreeissuedwithapurposetoprotectdownloadedmusicfromtheftbyconsumers.
3.LackofstandardizationinDRMmakessongsboughtforonekindofmusicplayermaynotfunctiononanother.
4.ApplehasbeencriticizedbyEuropeanregulatorssinceithasrefusedtograntalicenseFairPlaytootherfirms.
5.Allmusiccanbeeasilyplayedonnon-iPodmusicdevicesfromSonyorMicrosoftwithouttoomuchfiddling.
6.AppledependsfarmoreonDRMratherthanbrandingforitsdominanceofthedigitalmusicdevices.
7.IfDRMwascancelled,Sonywouldcertainlydominatetheinternationaldigitalmusicmarket.
Questions8-10
ChoosetheappropriatelettersA-Dandwritetheminboxes8-10onyouranswesheet.
8.WhichofthefollowingstatementsaboutMr.Jobs’ideaofDRMisNOTTRUE?
A.DRMplacesrestrictionsonconsumer’choiceofdigitalmusicproductsavailable.
B.DRMcomplesiTunesbuyerstoswitchtoadevicemadebySonyorMicrosoft.
C.DRMconstitutesabarrierforpotentialconsumerstoenterdigitalmusicmarkets.
D.DRMhindersdevelopmentofmorestoresandplayersandtechnicalinnovation.
9.Theword“unfazed”inline3ofparagraphE,means___________.
A.refused
B.welcomed
C.notbothered
D.notwellreceived
10.WhichofthefollowingstatementsisTRUEifDRMwasscapped?
A.Sonywouldgainthemostprofit.
B.Morecustomerswouldbe“lockedin”.
C.Asuddenincreaseinpiracywouldoccur.
D.Online-musicsaleswouldprobablydecrease.
Questions11-14
Completethenotesbelow.
ChooseNOMORETHANTHREEWORDSfromReadingPassage1foreachanswer.
Writeyouranswersinboxes11-14onyouranswersheet.
Mr.SteveJobs,thebossofApple,explainsthereasonwhyheusedtodefendDRM,sayingthatthecompanywasforcedtodoso:therecordcompanieswouldmaketheirmusicaccessibleto…11...onlyiftheyagreedtoprotectitusingDRM;theycanstill…12…iftheDRMsystemiscompromised.HealsoprovidesthereasonwhyAppledidnotlicenseFairPlaytoothers:thecompanyreliesonthemto…13….ButnowhechangeshismindwithapossibleexpectationthatEurope’sregulatorswouldnottroublehimanymoreinthefuture.Heproposesthatthosewhoareunsatisfactorywiththecurrentsituationindigitalmusicmarketshould…14…towardspersuadethemusiccompaniestoselltheirmusicDRM-free.
-----Tinahadnothingforbreakfast,____________she?
-----_____________.Shehadsomebreadandmilk.
newweapontofightcancer
1.Britishscientistsarepreparingtolaunchtrialsofaradicalnewwaytofightcancer,whichkillstumoursbyinfectingthemwithviruseslikethecommoncold.
2.Ifsuccessful,virustherapycouldeventuallyformathirdpillaralongsideradiotherapyandchemotherapyinthestandardarsenalagainstcancer,whileavoidingsomeofthedebilitatingside-effects.
3.LeonardSeymour,aprofessorofgenetherapyatOxfordUniversity,whohasbeenworkingonthevirustherapywithcolleaguesinLondonandtheUS,willleadthetrialslaterthisyear.CancerResearchUKsaidyesterdaythatitwasexcitedbythepotentialofProfSeymour’spioneeringtechniques.
4.Oneofthecountry’sleadinggeneticists,ProfSeymourhasbeenworkingwithvirusesthatkillcancercellsdirectly,whileavoidingharmtohealthytissue."Inprinciple,you’vegotsomethingwhichcouldbemanytimesmoreeffectivethanregularchemotherapy,"hesaid.
5.Cancer-killingvirusesexploitthefactthatcancercellssuppressthebody’slocalimmunesystem."Ifacancerdoesn’tdothat,theimmunesystemwipesitout.Ifyoucangetavirusintoatumour,virusesfindthemaverygoodplacetobebecausethere’snoimmunesystemtostopthemreplicating.Youcanregarditasthecancer’sAchilles’heel."
6.Onlyasmallamountofthevirusneedstogettothecancer."Theyreplicate,yougetamillioncopiesineachcellandthecellburstsandtheyinfectthetumourcellsadjacentandrepeattheprocess,"saidProfSeymour.
7.Preliminaryresearchonmiceshowsthatthevirusesworkwellontumoursresistanttostandardcancerdrugs."It’saninterestingpossibilitythattheymayhaveanadvantageinkillingdrug-resistanttumours,whichcouldbequitedifferenttoanythingwe’vehadbefore."
8.Researchershaveknownforsometimethatvirusescankilltumourcellsandsomeaspectsoftheworkhavealreadybeenpublishedinscientificjournals.Americanscientistshavepreviouslyinjectedvirusesdirectlyintotumoursbutthistechniquewillnotworkifthecancerisinaccessibleorhasspreadthroughoutthebody.
9.ProfSeymour’sinnovativesolutionistomaskthevirusfromthebody’simmunesystem,effectivelyallowingthevirusestodowhatchemotherapydrugsdo-spreadthroughthebloodandreachtumourswherevertheyare.Thebighurdlehasalwaysbeentofindawaytodelivervirusestotumoursviathebloodstreamwithoutthebody’simmunesystemdestroyingthemontheway.
10."Whatwe’vedoneismakechemicalmodificationstothevirustoputapolymercoataroundit-it’sastealthviruswhenyouinjectit,"hesaid.
11.Afterthestealthvirusinfectsthetumour,itreplicates,butthecopiesdonothavethechemicalmodifications.Iftheyescapefromthetumour,thecopieswillbequicklyrecognisedandmoppedupbythebody’simmunesystem.
12.Thetherapywouldbeespeciallyusefulforsecondarycancers,calledmetastases,whichsometimesspreadaroundthebodyafterthefirsttumourappears."There’sanawfulstatisticofpatientsinthewest...withmalignantcancers;75%ofthemgoontodiefrommetastases,"saidProfSeymour.
13.Twovirusesarelikelytobeexaminedinthefirstclinicaltrials:adenovirus,whichnormallycausesacold-likeillness,andvaccinia,whichcausescowpoxandisalsousedinthevaccineagainstsmallpox.Forsafetyreasons,bothwillbedisabledtomakethemlesspathogenicinthetrial,butProfSeymoursaidheeventuallyhopestousenaturalviruses.
14.Thefirsttrialswilluseuncoatedadenovirusandvacciniaandwillbedeliveredlocallytolivertumours,inordertoestablishwhetherthetreatmentissafeinhumansandwhatdoseofviruswillbeneeded.Severalmoreyearsoftrialswillbeneeded,eventuallyalsoonthepolymer-coatedviruses,beforethetherapycanbeconsideredforuseintheNHS.Thoughtheapproachwillbeexaminedatfirstforcancersthatdonotrespondtoconventionaltreatments,ProfSeymourhopesthatonedayitmightbeappliedtoallcancers.
Questions1-6
Dothefollowingstatementsagreewiththeinformationgiveninthereadingpassage?Forquestions1-6write
TRUEifthestatementagreeswiththeinformation
FALSEifthestatementcontradictstheinformation
NOTGIVENifthereisnoinformationonthisinthepassage
1.Virustherapy,ifsuccessful,hasanadvantageineliminatingside-effects.
2.CancerResearchUKisquitehopefulaboutProfessorSeymour’sworkonthevirustherapy.
3.Viruscankillcancercellsandstopthemfromgrowingagain.
4.Cancer’sAchilles’heelreferstothefactthatvirusmaystaysafelyinatumorandreplicate.
5.Toinfectthecancercells,agooddealofvirusesshouldbeinjectedintothetumor.
6.Researchesonanimalsindicatethatviruscouldbeusedasanewwaytotreatdrug-resistanttumors.
Question7-9
Basedonthereadingpassage,choosetheappropriateletterfromA-Dforeachanswer.
7.Informationaboutresearchesonviruseskillingtumorcellscanbefound
(A)onTV
(B)inmagazines
(C)oninternet
(D)innewspapers
8.Totreattumorsspreadingoutinbody,researcherstryto
(A)changethebody’immunesystem
(B)injectchemotherapydrugsintobloodstream.
(C)increasetheamountofinjection
(D)disguisethevirusesonthewaytotumors.
9.Whenthechemicalmodifiedvirusintumorreplicates,thecopies
(A)willsoonescapefromthetumorandspreadout.
(B)willbewipedoutbythebody’simmunesystem.
(C)willbeimmediatelyrecognizedbytheresearchers.
(D)willeventuallystopthetumorfromspreadingout.
Questions10-13
Completethesentencesbelow.Chooseyouranswersfromthelistofwords.Youcanonlyuseeachwordonce.
NBTherearemorewordsinthelistthanspacessoyouwillnotusethemall.
Inthefirstclinicaltrials,scientistswilltryto……10……adenovirusandvaccinia,soboththeviruseswillbelesspathogenicthanthe……11…….Theseuncoatedviruseswillbeapplieddirectlytocertainareastoconfirmsafetyonhumanbeingsandtheright……12……needed.Theexperimentswillfirstlybe……13……tothetreatmentofcertaincancers